Related Experiment Video

Updated: Jan 15, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.0K

Resistant Blood Pressure: New Frontiers in Interventional Hypertension Therapy

Jeffrey D Taylor1, Chukwunonyelum Uche2, Vanessa Rowe2

  • 1Department of Cardiology, University of Illinois Chicago, Chicago, IL, USA. jtaylo68@uic.edu.

Cardiology and Therapy
|October 10, 2025
PubMed

Insights

Interventional therapies targeting sympathetic overactivity offer new hope for managing difficult hypertension. Renal denervation shows promise, but secondary causes must be ruled out first.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Neurology

Background:

  • Hypertension affects over 1.3 billion globally, a major cause of cardiovascular disease.
  • Sympathetic overactivity and autonomic dysregulation are key in hypertension development.
  • Interventional device-based therapies are emerging for hypertension management.

Purpose of the Study:

  • To review evolving interventional device-based therapies for hypertension.
  • To highlight the role of these therapies in resistant hypertension (RH).
  • To emphasize the importance of managing secondary hypertension causes.

Main Methods:

  • Overview of current interventional approaches: renal denervation (RDN), baroreceptor activation therapy (BAT), carotid body modulation, hepatic denervation, cardiac neuromodulation.
  • Review of clinical trial evidence for these therapies.
  • Discussion on the necessity of diagnosing secondary hypertension.

Main Results:

  • RDN has the most substantial clinical trial evidence among interventional therapies.
  • Other neuromodulatory strategies are in early-phase studies.
  • Systematic identification and management of secondary hypertension are crucial before interventions.

Conclusions:

  • Interventional therapies show potential as adjuncts for hypertension management, particularly RH.
  • RDN is the most established interventional therapy currently.
  • Future precision-based hypertension management may incorporate these advanced therapies.

Keywords:
Baroreceptor activationEndovascular therapyInterventional cardiologyInterventional therapyRenal denervationResistant hypertensionSecondary hypertension

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

676
Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta08:08

Two-photon Imaging of Intracellular Ca2+ Handling and Nitric Oxide Production in Endothelial and Smooth Muscle Cells of an Isolated Rat Aorta

Published on: June 10, 2015

11.8K

Related Concept Videos

Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
621
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
787
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.7K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
932
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
467
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
357