TargetRX Atlas: a database of experimentally supported mRNAs and drug targets in disease

The role of mRNAs in the occurrence, development, and treatment of diseases has been extensively studied in recent years. For basic researchers, the vast amount of disease-related data is becoming increasingly complex and difficult to integrate and analyze. Herein, we developed the TargetRX Atlas (http://www.targetrx-atlas.cn/), a manually curated database that encompasses experimentally validated relationships between diseases, coding RNAs, and drug targets. The latest iteration of the TargetRX Atlas incorporates data from 1925 scientific articles and provides support for the role of drugs that act on mRNAs in disease treatment. Additionally, the database includes 1881 articles documenting the impact of mRNAs on the progression of diseases. The database currently features 13047 entries, encompassing 2014 mRNAs, 1196 drugs, and 689 diseases, thereby providing a robust platform for researchers in the fields of pharmacological research and disease treatment. The TargetRX Atlas database is expected to emerge as an invaluable resource for both clinical practice and basic research. This database not only enhances our understanding of the impact of drugs on mRNAs in human diseases but also provides predictions for drug targets based on existing experiments involving diseases and mRNAs. This resource is expected to significantly contribute to the advancement of personalized medicine and targeted therapies.