Related Experiment Video

Updated: May 12, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.5K

Comparison of Cutibacterium avidum Versus acnes in Periprosthetic Hip Infections: A Matched Cohort Analysis

J A Mitterer1, R M Kinsky2, Bjh Frank3

  • 1Michael Ogon Laboratory for Orthopaedic Research, Orthopaedic Hospital Speising, Vienna, Austria; Center for Anatomy and Cell Biology, Medical University Vienna, Vienna, Austria.

The Journal of Arthroplasty
|October 10, 2025
PubMed
Abstract

Insights

Cutibacterium avidum and Cutibacterium acnes cause distinct outcomes in revision total hip arthroplasty (rTHA). C. avidum is linked to PJI in obese patients, while C. acnes shows higher early septic failure rates.

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Microbiology

Background:

  • The role of Cutibacterium species in periprosthetic joint infections (PJIs) and unexpected positive intraoperative cultures (UPIC) after revision total hip arthroplasty (rTHA) is not fully understood.
  • Limited data exists on the comparative prevalence, clinical outcomes, and microbiological profiles of Cutibacterium avidum versus Cutibacterium acnes.

Purpose of the Study:

  • To investigate and compare the clinical outcomes and related factors in rTHA cases associated with Cutibacterium avidum and Cutibacterium acnes.

Main Methods:

  • Analysis of 636 culture-positive rTHA cases from 564 patients (2011-2021) with a minimum 40-month follow-up.
  • Evaluation of clinical presentation, risk factors, infection types (PJI vs. UPIC), and antibiotic resistance for C. avidum and C. acnes.
  • Propensity-score matching (1:3) to compare outcomes between the two pathogens.

Main Results:

  • Cutibacteria were identified in 18.9% of rTHA cases (C. avidum: 24, C. acnes: 96).
  • C. avidum was more frequently associated with true-septic PJIs (83.3%) and the direct anterior approach (DAA), higher BMI, and ASA scores.
  • C. acnes showed a more even distribution between PJI and UPIC, with higher early septic failure rates in PJI cases and increased antibiotic resistance observed for C. avidum.

Conclusions:

  • Clinically significant differences exist between C. avidum and C. acnes in rTHA.
  • C. avidum is more likely to cause PJI in obese patients undergoing DAA.
  • C. acnes is a clinically important pathogen in rTHA, associated with higher early septic failure rates.
Keywords:
Cutibacterium acnesCutibacterium avidumdirect anterior approachperiprosthetic joint infectionrevision hip arthroplasty

More Related Videos

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.8K
Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.3K

Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...