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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

468
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
468
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

338
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
338
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

401
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
401
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

369
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
369
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

502
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
502
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

453
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
453

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Related Experiment Video

Updated: Jan 15, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Coronary Microvascular Dysfunction Related to Hydroxychloroquine-Induced Cardiomyopathy.

Donald Richards1, Deeksha Acharya1, Serguei Bannykh1

  • 1Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, California, USA.

JACC. Case Reports
|October 10, 2025
PubMed
Summary

A rare case of drug-induced cardiomyopathy linked to hydroxychloroquine revealed coronary microvascular disease. This finding expands understanding of hydroxychloroquine toxicity and its impact on heart function.

Area of Science:

  • Cardiology
  • Pharmacology
  • Pathophysiology

Background:

  • A 69-year-old woman with rheumatoid arthritis experienced worsening chest pain.
  • Rheumatoid arthritis management often involves medications with potential cardiac side effects.
Keywords:
cardiomyopathyhydroxychloroquine (HCQ)microvascular dysfunctionrheumatoid arthritis (RA)

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