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Updated: Jan 15, 2026

Using Sniper-Cas9 to Minimize Off-target Effects of CRISPR-Cas9 Without the Loss of On-target Activity Via Directed Evolution
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UGI relocation inside Cas9 reduces Cas9 dependent off target effects in cytosine base editors

Zehao Shi1, Tian-Lin Cheng2

  • 1Institute of Pediatrics, Children's Hospital, Institutes for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.

Scientific Reports
|October 10, 2025
PubMed
Abstract

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