Related Experiment Video
Updated: Jun 26, 2026

Transcranial Electrical Brain Stimulation in Alert Rodents
Published on: November 2, 2017
Chronic alcohol-induced brain states limit propagation of direct cortical stimulation
Bettina Habelt1,2, Nasibeh Talebi3, Dzmitry Afanasenkau4
1Department of Psychiatry and Psychotherapy, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Abstract:
The impact of chronic alcohol consumption is evident in disruptions within prefrontal circuitries, resulting in cognitive deficits that underlie lost control over drinking. Given the limited efficacy of current pharmacotherapy, we employed multifunctional bioelectronics to investigate the potential of direct electrical brain stimulation to rectify neural impairments in alcohol-dependent rats. Cortical stimulation counteracted the observed deficiencies in event-related brain potentials and neural oscillations following chronic alcohol consumption, particularly by strengthening low-beta oscillations related to executive control. Stimulation efficacy thereby correlated with individual drinking patterns. In alcohol-dependent rats, stimulation-related neuroenhancement was spatially confined to the stimulation site, indicating reduced neural connectivity, as confirmed by a computational approach to directed functional connectivity patterns. Such state-dependent factors may contribute to the varying efficacy of brain stimulation observed in patients, ultimately suggesting the need for personalized neuromodulation designs.
More Related Videos
09:26Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
Published on: February 6, 2019
08:53Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
Related Concept Videos
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
GPCR Desensitization
CNS Depressants: Alcohol and Nicotine
Hepatic Encephalopathy
Chronic Pancreatitis II: Pathophysiology