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Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

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Updated: Jan 15, 2026

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

Constructing biomimetic microenvironments for liver regeneration.

Yawen Zhu¹, Wanqi Yang¹, Zhongxia Wang¹

¹Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing, 210008, China.

Journal of Nanobiotechnology

|October 11, 2025

Summary

This summary is machine-generated.

Biomimetic microenvironments offer innovative solutions for liver regeneration, addressing limitations of current therapies. Tissue engineering strategies enhance hepatic cell function and model liver diseases more accurately.

Keywords:

Biomaterials Biomimetic microenvironment Extracellular matrix Liver diseases Liver regeneration Tissue engineering

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Published on: April 18, 2025

Area of Science:

Biomedical Engineering
Regenerative Medicine
Hepatology

Background:

Liver regeneration is complex, influenced by microenvironment changes in disease.
Current liver therapies (transplantation, drugs) have limitations like donor shortage and immune rejection.
Novel strategies are needed to improve liver repair and function.

Purpose of the Study:

To review pathological features and biological basis of liver regeneration.
To discuss advanced biomimetic strategies for liver tissue engineering.
To highlight challenges and future directions in liver regeneration therapies.

Main Methods:

Review of literature on liver regeneration and biomimetic approaches.
Discussion of cellular plasticity, inflammation, ECM remodeling, and immune interactions.
Exploration of 3D cell cultures, decellularized ECM hydrogels, bioprinting, and dynamic bioreactors.

Main Results:

Biomimetic microenvironments recapitulate liver architecture and support hepatic functions.
Advanced biomimetic strategies enable accurate modeling of hepatic functions and cellular differentiation.
Tissue engineering approaches show potential for enhancing liver regeneration.

Conclusions:

Biomimetic microenvironments are promising for modeling liver regeneration and disease.
Tissue engineering offers innovative solutions to overcome limitations of current liver therapies.
Further research is needed for clinical translation, focusing on microenvironmental fidelity and scalability.