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Published on: October 19, 2013
Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models
Andrey D Volgin1, Sergey V Cheresiz1,2, Nadezhda D Chizhova1,2
1Scientific Research Institute of Neuroscience and Medicine, 630117 Novosibirsk, Russia.
Abstract:
Encoding a key 'hub' scaffolding protein, the 'Disrupted-In-Schizophrenia-1' (DISC1) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. DISC1 is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of DISC1-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (Danio rerio) models, to better understand the uniquely complex role of DISC1 in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.
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