Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models

Area of Science:

• Neuroscience
• Genetics
• Developmental Biology

Background:

• The Disrupted-In-Schizophrenia-1 (DISC1) gene encodes a scaffolding protein vital for brain development.
• Genetic variations in DISC1 are associated with major neuropsychiatric disorders like schizophrenia and bipolar disorder.
• DISC1 is widely expressed in the brain across species.

Purpose of the Study:

• To review existing animal models of DISC1-related brain deficits.
• To explore the clinical relevance of these models.
• To investigate conserved and species-specific mechanisms using novel zebrafish models.

Main Methods:

• Literature review of DISC1 animal models.
• Focus on conserved molecular mechanisms.
• Utilizing zebrafish (Danio rerio) models for neurobehavioral studies.

Main Results:

• Overview of DISC1 deficits in various animal models.
• Identification of shared and distinct phenotypes across species.
• Highlighting the utility of zebrafish models for studying DISC1 functions.

Conclusions:

• Animal models are essential for understanding DISC1's role in neuropsychiatric disorders.
• Zebrafish models offer a valuable platform for dissecting DISC1's complex functions.
• Further research in these models can elucidate DISC1's contribution to neurodevelopmental pathogenesis.