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Progressive Hippocampal Neuroarchitecture Changes in the 5×FAD Alzheimer's Disease Mouse Model
Hyewon Jang1, Sueun Lee2, Yeong-Jun Kim1
1College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, 61186 Gwangju, Republic of Korea.
Journal of Integrative Neuroscience
|October 11, 2025
Summary
Alzheimer
Area of Science:
- Neuroscience
- Alzheimer's Disease Research
Background:
- Neuroplasticity and synaptic homeostasis are crucial for hippocampal function.
- Alzheimer's disease (AD) involves cognitive decline, amyloid-beta (Aβ) plaques, tau tangles, neuroinflammation, and synaptic dysfunction.
- The progression of neuroplasticity impairments in the AD-vulnerable hippocampus remains unclear.
Purpose of the Study:
- To investigate age-dependent changes in behavioral performance.
- To examine hippocampal structural plasticity in the 5×FAD mouse model of Alzheimer's disease.
Main Methods:
- Evaluated 5×FAD mice at 3, 6, and 12 months of age.
- Assessed behavioral performance, including motor coordination and working memory.
- Analyzed hippocampal Aβ and tau pathology, neuroinflammation, dendritic complexity, spine density, and synaptic protein expression.
Main Results:
- 5×FAD mice showed progressive motor and memory deficits.
- Increased Aβ, phosphorylated tau, glial activation, and inflammatory cytokines were observed.
- Reduced dendritic complexity, altered spine density, and decreased synaptic protein expression (Arc, PSD-95) occurred with age.
Conclusions:
- AD pathology and neuroinflammation are linked to hippocampal structural plasticity impairments.
- These changes likely contribute to synaptic dysfunction and behavioral deficits in Alzheimer's disease.
