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Related Concept Videos

Ethnic Identity within a Larger Culture01:27

Ethnic Identity within a Larger Culture

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Adolescents from ethnic minority backgrounds face a multifaceted journey in forming their identities, shaped by the intersections of cultural expectations and personal exploration. For these adolescents, identity formation involves not only typical developmental challenges but also navigating the perceptions and attitudes of the majority culture. As they grow, adolescents in ethnic minority groups often become increasingly aware of stereotypes, social biases, and discrimination, all of which...
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Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
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  1. Home
  3. Research Domains
  5. History, Heritage And Archaeology
  7. Historical Studies
  9. European History (excl. British, Classical Greek And Roman)
  11. Founder Variants Of The Turkish.
  1. Home
  3. Research Domains
  5. History, Heritage And Archaeology
  7. Historical Studies
  9. European History (excl. British, Classical Greek And Roman)
  11. Founder Variants Of The Turkish.

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Founder Variants of the Turkish.

Ahmet Kablan1

  • 1Department of Medical Genetics, Ankara Etlik City Hospital, Ankara, Türkiye.

Clinical Genetics
|October 11, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Founder variants, or disease-causing genetic changes from a common ancestor, are prevalent in the Turkish population due to its complex history. These variants impact genetic counseling and rare disease research.

Keywords:
Turkish populationTürkiyecommon ancestorfounder variants

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Area of Science:

  • Population Genetics
  • Medical Genetics
  • Genomic Medicine

Background:

  • Founder variants are critical for understanding genetic diseases in isolated populations.
  • The Turkish population, situated at a demographic crossroads, exhibits a complex history of migration and admixture.
  • Founder variants are frequently linked to autosomal recessive disorders and are concentrated in consanguineous subpopulations.

Purpose of the Study:

  • To compile known founder variants within the Turkish population from existing literature.
  • To analyze the historical origins of these variants considering Anatolian population dynamics.
  • To discuss the implications of founder variants for genetic counseling, disease gene discovery, and precision medicine.

Main Methods:

  • Literature review of published studies on founder variants in the Turkish population.
  • Analysis of population dynamics and historical migration patterns in Anatolia.
  • Synthesis of findings to interpret variant origins and implications.

    • Main Results:

    • Numerous founder variants have been identified in the Turkish population, both domestically and internationally.
    • These variants are predominantly associated with autosomal recessive conditions.
    • A notable enrichment of founder variants is observed in subpopulations with high consanguinity rates.

    Conclusions:

    • Founder variants offer insights into the population genetics of Türkiye.
    • Understanding these variants is crucial for advancing rare disease research in Middle Eastern and Euro-Asian populations.
    • This knowledge supports the development of targeted genetic counseling and precision medicine strategies.