Predictive Factors for Failed Sentinel Lymph Node Mapping in Endometrial Cancer: A Retrospective Multicenter Study.

Area of Science:

• Gynecologic Oncology
• Surgical Oncology
• Cancer Diagnostics

Background:

• Sentinel lymph node (SLN) mapping is crucial for staging early-stage endometrial cancer (EC).
• Identifying factors predicting failed SLN mapping can optimize surgical planning and patient outcomes.
• Laparoscopic SLN mapping with intracervical indocyanine green (ICG) is a common technique.

Purpose of the Study:

• To identify predictive factors for failed SLN mapping in early-stage EC patients.
• To analyze clinical and pathological features associated with unsuccessful SLN detection.
• To improve the success rate of SLN mapping in EC treatment.

Main Methods:

• Retrospective analysis of 623 EC patients undergoing laparoscopic SLN mapping with ICG injection.
• Comparison of clinical and pathological features between successful bilateral and failed SLN mapping.
• Logistic regression analysis to determine independent predictors of failed SLN mapping.

Main Results:

• Successful bilateral SLN mapping was achieved in 70.14% of patients.
• Univariate analysis showed age, non-endometrioid histology, and previous vaginal delivery were associated with mapping failure.
• Multivariable analysis identified increasing age and non-endometrioid histology as independent predictors of failed SLN mapping.

Conclusions:

• Increasing age and non-endometrioid histology are significant independent predictors of failed bilateral SLN mapping in EC.
• These factors can help stratify patients at higher risk for unsuccessful SLN detection.
• Findings support personalized approaches to SLN mapping in EC management.