Anthropometric Changes and Systemic Inflammation After Sleeve Gastrectomy: Do Composite Markers Reflect the Change?

Area of Science:

• Bariatric Surgery
• Metabolic Health
• Inflammation Research

Background:

• Obesity is linked to chronic inflammation.
• Sleeve gastrectomy is a common bariatric procedure.
• Understanding its impact on inflammatory markers is crucial.

Purpose of the Study:

• To evaluate the effect of sleeve gastrectomy on inflammatory and nutritional markers.
• To assess the relationship between these markers and anthropometric changes post-surgery.

Main Methods:

• Retrospective analysis of 160 obese patients undergoing laparoscopic sleeve gastrectomy.
• Collected demographic, anthropometric, and laboratory data pre- and 6-months post-operation.
• Calculated various inflammatory scores (e.g., SII, PNI, LMR) and anthropometric measures (e.g., BMI, waist circumference).

Main Results:

• Significant reductions in body weight, BMI, waist circumference, and hepatic steatosis observed post-surgery.
• Key inflammatory markers and indices like SII and PIV decreased significantly, while LMR increased.
• No significant overall association found between anthropometric changes and inflammatory marker alterations.

Conclusions:

• Sleeve gastrectomy leads to substantial weight loss and reduced systemic inflammation.
• The observed inflammation reduction is not solely attributable to weight loss or body composition changes.
• Further research is needed to identify other factors influencing inflammation post-sleeve gastrectomy.