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Effect of Ocimum basilicum herbs extract on pro-inflammatory cytokines in ethanol-induced liver damage in rats
Hussein Talib Abdullah1, Almas M Al-Bayati2, Abbas Najm Aldin Saleh3
1DEPARTMENT OF BIOLOGY, COLLEGE OF SCIENCE FOR WOMEN, UNIVERSITY OF BAGHDAD, BAGHDAD, IRAQ.
Objective:
Aim: The aim of this study is to evaluate the hepatoprotective and immunomodulatory effects of Ocimum basilicum extract on pro-inflammatory cytokines, specifically TNF-α, IL-6, and IL-1β, in a rat model of ethanol-induced liver damage.
Patients And Methods:
Materials and Methods: A total of 120 male rats were divided into four groups: a control group, an ethanol-induced liver damage group, a low-dose basil treatment group, and a high-dose basil treatment group. Pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) were measured using ELISA.
Results:
Results: The ethanol exposure group showed significantly elevated TNF-α (548.8 ± 83.78 pg/mL), IL-6 (410.3 ± 167.7 pg/mL), and IL-1β (373.1 ± 127.7 pg/ mL) compared to the control group. Basil supplementation, particularly at high doses (100 mg/kg), effectively reduced these cytokines, with TNF-α (316.4 ± 57.37 pg/mL) and IL-6 (133.9 ± 86.76 pg/mL) levels approaching control values. IL-1β was also significantly reduced (152.3 ± 79.37 pg/mL) but remained slightly elevated.
Conclusion:
Conclusions: This study showed that Ocimum basilicum extract has potent hepato protective and anti-inflammatory properties, making it a promising natural therapeutic agent for alcohol-induced liver damage.
