Effect of short duration vitamin E supplementation on some reproductive hormones in infertile women

Aim: To study the effects of short duration vitamin E supplementation (100 mg/day) on reproductive hormones disturbance estrogen, follicle stimulating hormone, luteinizing hormone, and prolactin.

Materials and Methods: The study included 40 women with ages ranged between 18-35 years; they were treated from infertility at Al-Zahraa Teaching Hospital in Al-Najaf City in Iraq between June 2023 and May 2024. Women participated in the study were divided into two groups: Group (A): was given vitamin E supplementation (100 mg/day) starting at the 4th day of menstruation; Group (B): was given vitamin E supplementation (100 mg/day) starting at the mid of menstruation (expected ovulation time). The hormonal measurements for (Follicle Stimulating Hormone, Luteinizing Hormone, estradiol and prolactin) were conducted by immunoassay (Cobas E 411).

Results: The results revealed that there was a significant increase in blood level of E after treatment compared to their levels before treatment. The results also indicated that the levels of estradiol and Luteinizing Hormone have been elevated after intervention as compared to that before intervention.

Conclusions: It was concluded the complementation of vitamin E supplementation (100 mg/day) has a positive impact in the enhancement of female hormonal indicators (especially estradiol and Luteinizing Hormone) which may increase the efficiency of the therapeutic approaches of infertility. Early-cycle supplementation also resulted in higher estradiol (P=0.04) and luteinizing hormone levels (P=0.02) compared with mid-cycle supplementation, indicating increased hormonal activity.