Magnesium Sulfate-Mediated Inflammatory Modulation in High-Risk Pregnancies: Dynamic Shifts in CBC-Derived Markers...

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Neonatal Medicine

Background:

• High-risk pregnancies often involve interventions like magnesium sulfate (MgSO4) therapy.
• Maternal inflammatory markers can reflect systemic changes during pregnancy.
• Understanding hematologic shifts during MgSO4 treatment is crucial for assessing maternal and fetal well-being.

Purpose of the Study:

• To evaluate the impact of MgSO4 therapy on dynamic changes in maternal inflammation-based hematologic indices.
• To assess the predictive value of these hematologic changes for neonatal outcomes in high-risk pregnancies.

Main Methods:

• Retrospective cohort study of 236 singleton pregnancies receiving MgSO4.
• Comparison of complete blood count (CBC)-derived inflammatory markers (NLR, PLR, SIRI, MPV) pre- and 24-h post-treatment.
• Analysis of percentage changes (Δ) and their correlation with adverse perinatal outcomes using ROC curves.

Main Results:

• MgSO4 administration significantly altered maternal inflammatory markers: increased NLR, WBC, SIRI; decreased PLR, LMR, platelet count (p < 0.05).
• ΔNLR, ΔMPV, and ΔWBC correlated negatively with gestational age and birth weight, and positively with NICU admission.
• ΔNLR ≥ -15.132 predicted NICU admission (AUC = 0.609, p = 0.016).

Conclusions:

• Magnesium sulfate therapy induces measurable dynamic changes in maternal inflammatory hematologic profiles.
• These shifts, particularly in NLR and MPV, show limited predictive value for adverse neonatal outcomes.
• Monitoring Δ-inflammatory indices may aid risk stratification but requires further clinical validation.