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Updated: Jan 15, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Emerging strategies to enhance microbial natural product-based drug discovery
Michael Madden1, Conor Pulliam1, Katherine Holandez-Lopez1
1Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, United States; Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, United States.
Abstract:
Natural products (NPs) have served as a major source of chemically novel, bioactive therapeutics for the treatment of various diseases. In recent years, NP discovery has benefited greatly from advancements in biotechnological fields. This review covers techniques and tools from 2022 to 2025 that have expanded NP discovery capabilities through gene-editing tools to activate silent biosynthetic genes, cell-free methods for NP production and diversification, as well as artificial intelligence and informatics tools for structure generation and correlational studies.
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