Related Experiment Video
Updated: Jan 15, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Which 'dose rate' definition describes the FLASH sparing effect for scanned proton beams? A meta-analysis of skin
Isabella Colizzi1, Per Rugaard Poulsen2, Brita Sorensen3
1Center for Proton Therapy, Paul Scherrer Institut (PSI), 5232 Villigen, Switzerland; Department of Physics, ETH Zurich 8092 Zurich, Switzerland.
Abstract:
We compiled preclinical proton PBS skin toxicity data to assess how various dose rate definitions (field, average, and dose average) explain the FLASH sparing effect. Only average dose rate (ADR), accounting for 'effective irradiation time,' reliably describes it. We identified high-dose and ADR regions where the effect was consistently observed.
More Related Videos
07:57Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
06:21Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
Published on: May 27, 2016