Relationship between moderate alcohol consumption and all-cause mortality across different stages of
Zhuotong Wang1, Lingyuan Hu1, Aomiao Chen1
1Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; De Feng Academy, Southern Medical University, Guangzhou, China.
Insights
Moderate alcohol consumption may increase all-cause mortality, particularly in certain stages of Cardiovascular-Kidney-Metabolic Syndrome (CKM). This study suggests caution even with moderate drinking for both men and women.
Area of Science:
- Cardiovascular Health
- Metabolic Syndrome Research
- Public Health & Epidemiology
Background:
- The health impacts of moderate alcohol intake are debated.
- Cardiovascular-Kidney-Metabolic Syndrome (CKM) is an emerging health concept.
- Existing research lacks clarity on alcohol's role in CKM.
Purpose of the Study:
- To examine moderate alcohol consumption's link with all-cause mortality.
- To investigate this association across different CKM stages.
- To validate findings in UK Biobank and NHANES populations.
Main Methods:
- Analysis of UK Biobank (112,207 participants) and NHANES (10,904 participants) cohorts.
- Stratification by CKM stages and sex.
- Use of multiple covariates and restricted cubic spline (RCS) curves.
Main Results:
- UK Biobank showed moderate drinking linked to higher all-cause mortality; NHANES did not.
- Positive correlation found in CKM stages II (both sexes) and IV (males).
- RCS curves indicated higher female sensitivity to alcohol's mortality risk.
Conclusions:
- A positive association between alcohol consumption and all-cause mortality was observed.
- Findings suggest caution regarding moderate alcohol intake for both genders.
- Minimizing alcohol consumption is recommended despite potential prior perceived benefits.
Background And Aim:
The health effects of moderate alcohol consumption remain inconclusive. The Cardiovascular-Kidney-Metabolic Syndrome (CKM) is a novel concept that involves various health conditions. This study aimed to investigate the association between moderate alcohol consumption and all-cause mortality in different stages of CKM within the UK Biobank cohort, and to validate the findings in the NHANES population.
Methods And Results:
This study included 112,207 participants from the UK Biobank cohort, stratified by different stages of CKM. Multiple covariates were incorporated to explore the relationship between moderate alcohol consumption and all-cause mortality. Additionally, 10,904 participants from the NHANES cohort were analysed, stratified by sex, with restricted cubic spline (RCS) curves plotted for corroboration. In the UK Biobank, moderate alcohol consumption was associated with increased all-cause mortality, whereas no significant association was found in the NHANES cohort. Among the CKM stages, moderate drinking was positively correlated with all-cause mortality in males and females in stage II and males in stage IV, whereas no significant associations were observed in the other stages. The RCS curves revealed a positive correlation between alcohol consumption and all-cause mortality for both genders, with females showing greater sensitivity to alcohol than males.
Conclusions:
While previous studies have suggested potential benefits of moderate alcohol consumption, a positive correlation between alcohol consumption and all-cause mortality was observed for both genders in our study. Therefore, even moderate alcohol intake warrants caution, and efforts should be made to minimize alcohol consumption.
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