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Bioactive peptides: from preclinical to clinical studies
Guillermo Santos-Sánchez1, Marta Santos-Hernández2, Beatriz Miralles1
1Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM, CEI UAM+CSIC), Madrid, Spain.
Current Opinion in Clinical Nutrition and Metabolic Care
|October 12, 2025
Summary
Protein hydrolysates show promise for metabolic, cardiovascular, and immune health. Further clinical trials are needed to validate these benefits for food and pharmaceutical applications.
Area of Science:
- Nutritional Biochemistry
- Molecular Biology
- Immunology
Background:
- Growing interest in dietary components and health.
- Bioactive peptides are a key area of research.
- Therapeutic potential of peptides remains underutilized.
Purpose of the Study:
- Evaluate physiological effects of protein hydrolysates and peptide fractions.
- Focus on metabolic health, cardiovascular regulation, and immune function.
- Summarize recent preclinical and clinical evidence.
Main Methods:
- Review of preclinical studies.
- Analysis of clinical trials.
- Evaluation of protein hydrolysates and purified peptide fractions.
Main Results:
- Preclinical evidence suggests benefits for metabolic disorders (obesity, glucose homeostasis) and cardiovascular function.
- Hydrolysates modulate adaptive immune responses and are used in infant formulas.
- Intestinal epithelium is a key site of action via gut hormone release and microbiota modulation.
Conclusions:
- Protein hydrolysates show significant potential for metabolic, cardiovascular, and immune health.
- Further rigorous clinical trials are required for validation.
- Potential for incorporation into food and pharmaceutical formulations.
