Nanofibrous smart wound dressing based on pH-responsive methacrylates copolymers: A review

Electrospinning is a versatile and eco-friendly method for producing ultra-fine nanofibers from various polymers. Among them, Eudragit® (a family of methacrylate copolymers) has gained prominence due to its pH-responsive solubility and pharmaceutical-grade biocompatibility. Nanofibers derived from Eudragit not only enhance drug delivery and moisture retention but also offer smart functionalities for wound healing. Given the pivotal role of pH in regulating infection control, angiogenesis, enzyme activity, and tissue regeneration, pH-sensitive wound dressings can significantly accelerate healing, especially in chronic wounds with elevated alkalinity. This review provides a comprehensive examination of Eudragit based electrospun nanofibers for wound healing applications. It thoroughly assesses the solvent parameters influencing electrospinning efficiency and morphology, considering how different pH conditions in the wound microenvironment modulate fiber performance and drug release behavior. The central focus of this review is to integrate physicochemical insights with biological relevance, highlighting how pH-responsive nanofibers can be engineered to match wound pathophysiology. By consolidating recent research, this study aims to offer technical guidance for designing next-generation wound dressings with responsive capabilities. The findings serve as a roadmap for optimizing Eudragit electrospun systems tailored for targeted, phase-specific wound treatment.