Nanofibrous smart wound dressing based on pH-responsive methacrylates copolymers: A review

Area of Science:

• Materials Science
• Biomedical Engineering
• Polymer Chemistry

Background:

• Electrospinning produces ultra-fine nanofibers from polymers like Eudragit®, known for pH-responsive solubility and biocompatibility.
• Eudragit nanofibers enhance drug delivery, moisture retention, and offer smart functionalities for wound healing.
• Wound healing is pH-dependent, making pH-sensitive dressings crucial for chronic wounds with altered pH.

Purpose of the Study:

• To comprehensively review Eudragit-based electrospun nanofibers for wound healing.
• To assess solvent parameters affecting electrospinning and fiber morphology.
• To explore how wound microenvironment pH modulates fiber performance and drug release.

Main Methods:

• Review of existing literature on Eudragit electrospinning and wound healing applications.
• Analysis of physicochemical properties of Eudragit nanofibers.
• Integration of fiber properties with wound pathophysiology and pH modulation.

Main Results:

• Eudragit nanofibers exhibit tunable properties based on electrospinning parameters and pH.
• pH-responsive behavior of Eudragit nanofibers can be engineered for controlled drug release.
• Nanofiber performance is significantly influenced by the wound microenvironment's pH.

Conclusions:

• Eudragit electrospun nanofibers represent a promising platform for advanced wound dressings.
• Engineering pH-responsive nanofibers can lead to targeted, phase-specific wound treatment.
• This review provides guidance for developing next-generation smart wound healing systems.