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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Placental Role in Fetal Neonatal Neurologic Outcomes

Lina F Chalak1, Lynn Bitar2, Rachel Leon2

  • 1Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center and Children's Medical Center, Neurological Neonatal Intensive Care Unit (NeuroNICU) Program Fetal and Neonatal, UT Southwestern Medical Center, 5323 Harry Hines Dallas, TX, 75390-9063, USA; Division of Neonatal-Perinatal Medicine, Department of Pediatrics, UT Southwestern Medical Center, 5323 Harry Hines Dallas, TX, 75390-9063, USA.

Pediatric Clinics of North America
|October 12, 2025
PubMed

Neuroplacentology explores the intricate relationship between the placenta, fetal brain development, and long-term neurologic outcomes. As the primary interface between mother and fetus, the placenta regulates the transfer of nutrients, oxygen, and waste products essential for growth and development. Disruptions in placental function and maternal conditions, such as preeclampsia and intrauterine growth restriction, can lead to preterm birth and brain injury. This neuro-placentology review highlights the impact of placental dysfunction on prematurity, hypoxic-ischemic encephalopathy, and congenital heart disease in the neonatal intensive care unit.

Keywords:
Congenital heart diseaseHypoxic-ischemic encephalopathyImagingInflammationNeurodevelopmentPlacentaPreterm neonates

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