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Updated: Jun 24, 2026

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Luteolin Inhibits NLRP3 Inflammasome Activation to Ameliorate DSS-Induced Colitis by Regulating AMPK Signalling

Lianxiang Luo1, Fangfang Huang2, Guixuan Fang2

  • 1School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, Guangdong, China.

Cell Proliferation
|October 12, 2025
PubMed
Summary

Luteolin, a natural compound, effectively treats ulcerative colitis in mice by inhibiting the NLRP3 inflammasome. This anti-inflammatory action involves reducing cellular stress and improving lipid metabolism, highlighting its therapeutic potential for inflammatory bowel disease.

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