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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

881
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

252
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

307
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
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Racial Disparities in Pediatric Intestinal Transplant Wait-List Times Are Not Explained by Socioeconomic Measures.

Susan A Gutierrez1, Tianna M Truby1, Vikram Raghu2

  • 1Department of Pediatrics, University of California, San Francisco, California, USA.

Pediatric Transplantation
|October 13, 2025
PubMed
Summary

Racial disparities persist in pediatric intestinal transplant wait times, with non-White children experiencing significantly longer waits. These inequities suggest barriers beyond socioeconomic factors require further investigation for equitable care.

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Area of Science:

  • Pediatric Gastroenterology
  • Transplant Surgery
  • Health Equity Research

Background:

  • Racially minoritized children with intestinal failure face higher mortality and lower transplant rates.
  • Socioeconomic factors' role in transplant disparities is not well understood.

Purpose of the Study:

  • To investigate racial disparities in pediatric intestinal transplant wait times and post-transplant outcomes.
  • To assess the influence of socioeconomic factors on these disparities.

Main Methods:

  • Analysis of pediatric intestinal transplant recipients from the Scientific Registry of Transplant Recipients (2002-2021).
  • Inclusion of hospitalization data from the Pediatric Health Information System (2004-2023).
  • Race and neighborhood income were analyzed, adjusting for insurance status.

Main Results:

  • Non-White children experienced significantly longer wait-list times (1034 vs. 442 days) compared to White children.
  • These racial disparities in wait times persisted after adjusting for neighborhood income and insurance.
  • No significant racial differences were found in inpatient bed days, hospitalization risk, or 30-day readmission rates.

Conclusions:

  • Racial disparities in pediatric intestinal transplant wait times are significant and not fully explained by socioeconomic factors.
  • Additional barriers likely exist, necessitating further research to ensure equitable access to transplantation.
  • Strategies are needed to address inequities and improve timely transplant access for all children.