Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The periaqueductal gray and its role in the neural control of lower urinary tract function.

Autonomic neuroscience : basic & clinical·2026
Same author

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI-RS 2025.

Neurourology and urodynamics·2025
Same author

Breakfast consumption does not rapidly increase liver or muscle glycogen content in well-trained cyclists.

American journal of physiology. Endocrinology and metabolism·2025
Same author

Visual and Auditory Object Representations in Ventral Visual Cortex After Restoring Sight in Humans.

Human brain mapping·2025
Same author

Carbohydrate intake of 10 g/kg body mass rapidly replenishes liver, but not muscle glycogen contents, during 12 h of post-exercise recovery in well-trained cyclists.

The Journal of physiology·2025
Same author

Depression as a mediator in the relationship between adverse childhood events, pelvic pain, and pelvic organ prolapse: A cross-sectional study using structural equation modeling.

Journal of psychosomatic research·2025

Related Experiment Video

Updated: Jan 15, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.3K

Altered Periaqueductal Gray Functional Connectivity in Overactive Bladder Patients: A Resting-State Functional

Susana Fernández Chadily1, Naomi R van Houtum1, Marianne E van Klaveren1

  • 1Department of Urology, Mental Health and Neuroscience Research Institute, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands.

International Neurourology Journal
|October 13, 2025
PubMed
Summary

Overactive bladder patients show static brain-bladder signaling in the periaqueductal gray (PAG), unlike healthy individuals. This lack of dynamic PAG reorganization may contribute to overactive bladder (OAB) pathophysiology.

Keywords:
Brain mappingFunctional magnetic resonance imagingOveractive bladderPeriaqueductal gray

More Related Videos

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.3K
Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements
10:07

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements

Published on: January 30, 2018

16.7K

Related Experiment Videos

Last Updated: Jan 15, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

2.3K
Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

Published on: April 27, 2014

18.3K
Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements
10:07

Cystometric and External Urethral Sphincter Measurements in Awake Rats with Implanted Catheter and Electrodes Allowing for Repeated Measurements

Published on: January 30, 2018

16.7K

Area of Science:

  • Neuroscience
  • Urology
  • Medical Imaging

Background:

  • Overactive bladder (OAB) syndrome significantly impacts quality of life, with unclear pathophysiology.
  • Disruption of the brain-bladder neural network, particularly the periaqueductal gray (PAG), is implicated in OAB.
  • The PAG is crucial for bidirectional communication within the brain-bladder axis.

Purpose of the Study:

  • To investigate dynamic changes in functional connectivity-based organization of the PAG over time.
  • To compare PAG organization between OAB patients and healthy controls (HC).

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) at 7 Tesla was used.
  • Participants included OAB patients and HC with an empty bladder.
  • Functional connectivity-based clustering analysis evaluated time-dependent PAG organization.

Main Results:

  • Significant group differences in time-dependent PAG functional organization were observed (P=0.017).
  • Healthy controls exhibited dynamic reorganization of PAG subdivisions during the scan.
  • OAB patients displayed largely static PAG functional organization with minimal temporal change.

Conclusions:

  • Findings suggest altered PAG signaling and sensory processing in OAB patients.
  • The absence of dynamic PAG reorganization may be a contributing factor to OAB pathophysiology.
  • This study provides new insights into the neural mechanisms underlying OAB.