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A Case of Drug-Induced CA72-4 Pseudo-Elevation and Analysis of Its Causes

Hong-Gang Sun, Jian-Qing Zhang, Ying Zhang

    Clinical Laboratory
    |October 13, 2025
    PubMed
    Abstract

    Insights

    Colchicine, a medication for gout, can falsely elevate CA72-4 cancer marker levels. Discontinuing colchicine normalized CA72-4, preventing misdiagnosis and unnecessary anxiety.

    Area of Science:

    • Oncology
    • Clinical Chemistry

    Background:

    • CA72-4 is a key tumor marker for gastrointestinal and ovarian cancers.
    • Colchicine use can lead to spurious elevations in serum CA72-4.
    • This interference may cause misinterpretation as a cancer signal, leading to patient anxiety and unnecessary investigations.

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