Effects of different exercise interventions on bone mineral density in elderly postmenopausal women: a network
Mingyu Ma1, Wentao Su1, Dansong Liu1
1School of Physical Education, Hubei University of Technology, Wuhan, Hubei, China.
Background:
Various exercise interventions have been widely applied to enhance site-specific bone mineral density in menopausal females. This network meta-analysis aims to assess and compare the impact of these interventions on improving BMD in this demographic.
Methods:
A systematic search of PubMed, EMBASE, Cochrane Library, and Web of Science was made up to 4 December 2024 to detect randomized controlled trials (RCTs) comparing continuous endurance training whole-body vibration resistance training multicomponent training mind-body training intermittent training and combined training against control interventions. Primary outcomes included lumbar spine bone mineral density and femoral neck bone mineral density while secondary outcomes covered whole body bone mineral density and total hip bone mineral density A Bayesian random-effects NMA was performed.
Results:
Fifty-five RCTs involving 3,453 participants were included. Compared with the control group, MCT demonstrated greater efficacy in improving FNBMD (mean difference [MD] 0.02; 95% credible interval [CrI] [0.01, 0.04]). Based on the surface under the cumulative ranking (SUCRA), MBT ranked highest for LSBMD (75.9%), CT for WBBMD (77.6%), and MBT for THBMD (60.7%), suggesting potential benefits of these interventions.
Conclusion:
This study suggests that MBT, MCT, and CT may contribute to improving BMD in elderly postmenopausal women. However, further rigorously designed RCTs are warranted to validate these findings.
Systematic Review Registration:
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42025636067.
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:40Bone Remodeling
01:20Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
01:25Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age