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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
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Current Advances in Nanocarriers for Cancer Therapy.

Reza Zeinali1, Davood Zaeifi2, S Yasaman Zolfaghari-Moghaddam3

  • 1Group of Molecular and Industrial Biotechnology, Department of Chemical Engineering, Universität Politècnica de Catalunya, Terrassa, Spain.

International Journal of Nanomedicine
|October 13, 2025
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Nanocarriers effectively deliver therapeutic compounds by overcoming drug resistance and cell barriers. This review explores strategies to enhance nanocarrier efficiency for precise cancer treatment delivery.

Keywords:
cancerdrug delivery systemdrug resistancenanocarriersnanotechnology

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Nanocarriers offer significant potential for encapsulating and delivering bioactive compounds to target cells.
  • Intracellular barriers and drug resistance present major challenges in drug delivery.
  • Effective drug delivery is crucial for optimal therapeutic outcomes in various diseases, particularly cancer.

Purpose of the Study:

  • To review the challenges posed by drug resistance and cell barriers in nanocarrier-mediated drug delivery.
  • To explore recent advances and novel strategies for overcoming these obstacles.
  • To provide an overview of nanocarrier types for cancer therapy and their future prospects.

Main Methods:

  • Literature review focusing on nanocarrier-based drug delivery systems.
  • Analysis of strategies to enhance cell internalization, intracellular trafficking, and targeted delivery.
  • Discussion of methods for controlled drug release and overcoming multidrug resistance.

Main Results:

  • Nanocarriers can be engineered to navigate intracellular barriers and evade resistance mechanisms.
  • Novel strategies improve nanocarrier efficiency in targeting specific subcellular locations.
  • Controlled drug release from nanocarriers enhances therapeutic efficacy and reduces side effects.

Conclusions:

  • Nanocarriers hold great promise for precise and effective drug delivery in cancer therapy.
  • Continued research into nanocarrier design and targeting strategies is essential.
  • This review provides insights for developing advanced nanocarriers for diverse therapeutic applications.