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A Design of Copper(II) Coordination Polymers with l‑Homoserine: Structural, Spectroscopic, and Biological Studies
Darko Vušak1, Ivana Kekez1, David Kučera-Čavara1
1Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, Zagreb 10000, Croatia.
ACS Omega
|October 13, 2025
Summary
Five new copper(II) coordination polymers were synthesized using l-homoserinate and 2,2'-bipyridine. One compound, 2·2H2O, showed anticancer and antibacterial properties, with potential for further development.
Area of Science:
- Coordination Chemistry
- Materials Science
- Biomedical Applications
Background:
- Copper(II) coordination polymers are of interest due to their diverse structures and potential applications.
- l-Homoserinate (l-hser) and 2,2'-bipyridine (bpy) are versatile ligands for creating novel metal-organic frameworks.
- Understanding structure-property relationships is crucial for designing functional materials.
Purpose of the Study:
- To synthesize and characterize novel copper(II) coordination polymers using l-homoserinate and 2,2'-bipyridine.
- To investigate the structural diversity and polymerization mechanisms in these copper(II) complexes.
- To evaluate the biological activities and DNA binding affinities of the synthesized compounds.
Main Methods:
- Synthesis of five copper(II) coordination polymers (1a, 1b·H2O, 2·2H2O, 2·3H2O, 2·4H2O) via solution-based and mechanochemical methods.
- Solid-state characterization using single-crystal and powder X-ray diffraction (SCXRD, PXRD), EPR, Raman, IR spectroscopy, and thermogravimetric analysis (TGA).
- Solution characterization using UV-Vis spectroscopy, EPR, Raman spectroscopy, and fluorimetry; biological activity screening and DNA binding studies.
Main Results:
- Five copper(II) coordination polymers were successfully synthesized and characterized.
- Polymerization occurred through the hydroxyl group in binary compounds (1a, 1b·H2O) and the carboxylate group in ternary compounds (2·2H2O, 2·3H2O, 2·4H2O).
- Compound 2·2H2O exhibited moderate antiproliferative activity against lung, breast, and colon cancer cell lines and antibacterial activity against Moraxella catarrhalis. It showed lower binding affinity to dsDNA.
Conclusions:
- The study successfully synthesized and characterized novel copper(II) coordination polymers with distinct structural features.
- The choice of ligand and synthesis method influences the polymerization pathway and resulting coordination geometry.
- Compound 2·2H2O demonstrates promising biological activities, warranting further investigation for therapeutic applications.
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