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Updated: Jan 15, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Jejupeptins A and B, Polyketide-Cyclic Peptide Hybrids with Anti-Corticosterone Activity from Streptomyces sp.
Jun-Pil Jang1, Jongtae Roh1,2, Gil Soo Kim3
1Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, South Korea.
Abstract:
Two new lipopeptides jejupeptins A (1) and B (2), together with a known compound eurystatin B (3), were isolated from a culture of Streptomyces sp. KCB15JA151. The chemical structures of the compounds were elucidated by using a combination of 1D and 2D NMR spectroscopy analyses. Comprehensive spectroscopic analysis revealed that compounds 1 and 2 possess a 1-aminoethyl-2-hydroxy-4-oxopentanoic acid moiety. A plausible biosynthetic pathway for these compounds was proposed. Biological evaluation demonstrated that compounds 1 and 2 exhibit protective effects against corticosterone-induced apoptosis and cellular oxidative stress without any associated cytotoxicity.
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