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Sleep disturbances and heart failure: observational study and Mendelian randomization study
Junwen Wang1, Ziyi Sun2, Yi Zhong3
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
Archives of Medical Science : AMS
|October 13, 2025
Summary
Sleep disturbances like insomnia are linked to heart failure (HF). This study used observational data and Mendelian randomization to suggest a causal relationship, indicating that addressing sleep issues may lower HF risk.
Area of Science:
- Cardiology
- Sleep Medicine
- Genetics
Background:
- Sleep disturbances are common in heart failure (HF) patients and can worsen the condition.
- The exact causal link between sleep problems and HF has not been definitively established.
Purpose of the Study:
- To investigate the association between sleep disturbances and heart failure.
- To explore a potential causal relationship using Mendelian randomization.
Main Methods:
- An observational study analyzed NHANES data (2005-2008) from 10,432 participants, defining sleep disturbances broadly.
- A Mendelian randomization (MR) study utilized genetic variants associated with sleeplessness from GWAS data.
- Two-sample MR analysis was performed using summary statistics from sleeplessness and HF GWAS datasets.
Main Results:
- Observational analysis showed significant associations between insomnia (OR=5.10) and sleep disorders (OR=3.51) with HF.
- Mendelian randomization provided evidence for a causal link between sleeplessness and HF (IVW: OR=1.535; MR-Egger: OR=3.333).
- MR analysis helps mitigate confounding factors inherent in observational studies.
Conclusions:
- The study found a correlation between sleep disturbances and heart failure, suggesting a potential causal relationship.
- Interventions targeting sleep disturbances could be a crucial strategy for reducing heart failure risk.
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