Related Experiment Video
Updated: Jan 15, 2026
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
Alkaline phosphatase predicts short-term postoperative outcome in adult patients with moyamoya disease
Wei Sun1, Huihui Wang2, Qiheng He1
1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background:
Alkaline phosphatase (ALP) has played a pivotal role in vascular diseases in recent years. However, the association between ALP level and postoperative complications of moyamoya disease (MMD) has not been studied.
Patients And Methods:
Blood samples were collected from recruited patients with MMD. The serum ALP concentrations of the patients were determined using non-frozen specimens via an automated enzymatic assay. Patients were then divided into two groups according to the median, and a comparative analysis was performed. Patients were stratified into two cohorts for statistical evaluation based on the occurrence of postoperative stroke events. We employed a nomogram to identify risk factors for postoperative events. We also created a Cox model to analyze the risk factors for postoperative stroke events, including ALP. Furthermore, we plotted a restricted cubic spline (RCS) of ALP concentration vs. postoperative stroke events.
Results:
We could find that the ALP concentration of non-postoperative stroke group and postoperative stroke group was 68.70 U/L and 71.15 U/L. This nomogram showed that ALP was a risk factor for postoperative events, and the Hosmer-Lemeshow goodness-of-fit test was employed, suggesting that the model was reliable (χ2 = 8.507, p = 0.386). And it also could obverse that there was a statistically positive correlation from the RCS between ALP concentration and postoperative stroke events Cox analysis (HR = 1.006, 95% CI = 1.002-1.010, p = 0.008).
Conclusions:
ALP levels may predict the short-term postoperative outcomes of MMD patients undergoing surgical treatment.
Insights
Elevated alkaline phosphatase (ALP) levels may indicate a higher risk of postoperative stroke in patients with moyamoya disease (MMD). This finding suggests ALP can help predict short-term outcomes after MMD surgery.
Area of Science:
- Vascular Neurology
- Biochemistry
- Medical Diagnostics
Background:
- Alkaline phosphatase (ALP) is increasingly recognized for its role in vascular diseases.
- The relationship between ALP levels and postoperative complications in moyamoya disease (MMD) has not been previously investigated.
Purpose of the Study:
- To investigate the association between serum alkaline phosphatase (ALP) levels and postoperative stroke events in patients with moyamoya disease (MMD).
- To determine if ALP can serve as a predictive biomarker for short-term outcomes following surgical intervention for MMD.
Main Methods:
- Serum ALP concentrations were measured in MMD patients using an automated enzymatic assay.
- Patients were stratified based on median ALP levels and the occurrence of postoperative stroke.
- Cox regression analysis and restricted cubic splines (RCS) were utilized to assess ALP as a risk factor for postoperative stroke.
Main Results:
- A statistically significant positive correlation was observed between higher ALP concentrations and an increased risk of postoperative stroke events (HR = 1.006, p = 0.008).
- Nomogram analysis identified ALP as a risk factor for postoperative complications, with a reliable predictive model (χ² = 8.507, p = 0.386).
- The mean ALP level in the postoperative stroke group (71.15 U/L) was slightly higher than in the non-stroke group (68.70 U/L).
Conclusions:
- Serum alkaline phosphatase (ALP) levels show potential as a predictive biomarker for short-term postoperative outcomes in moyamoya disease (MMD) patients.
- This study highlights the clinical relevance of monitoring ALP levels to anticipate complications after MMD surgery.
More Related Videos
05:16Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
