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Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Related Experiment Video

Updated: Jan 15, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Navigating Penile Metastases: Personalized Management in a Rare Oncologic Challenge.

R Hamal¹, A Feyaerts¹, S Thiry¹

¹Department of Urology, University Hospital Saint-Luc, Brussels, Belgium.

Case Reports in Urology

|October 13, 2025

Summary

Penile metastasis from kidney cancer is rare. This case highlights a single penile metastasis of papillary renal cell carcinoma (pRCC) successfully treated with complete surgical excision, with no recurrence after 8 years.

Area of Science:

Urology
Oncology
Pathology

Background:

Secondary penile malignancy is uncommon, with most metastases originating from genitourinary or pelvic organs.

Keywords:

cancer metastasis penile renal cell carcinoma

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Metastases from extrapelvic primary sites are less frequent and often indicate widespread disease.

Renal cell carcinoma metastasis to the penis is exceptionally rare, with fewer than 50 reported cases.