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Oxidative Imbalance in Conversion Disorder: Evidence from Thiol-Disulphide Homeostasis Disruption
Hasan Büyükaslan1, Mehmet Asoğlu2, Mustafa Sever3
1Department of Emergency Medicine, Faculty of Medicine, Harran University, Şanlıurfa, Türkiye.
Conversion Disorder (CD) patients exhibit oxidative imbalance and elevated CRP levels, suggesting redox and inflammatory pathways are involved. Thiol/disulfide homeostasis and CRP may serve as peripheral biomarkers for this neuropsychiatric condition.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Conversion Disorder (CD) is a complex neuropsychiatric condition potentially influenced by stress-related biological changes.
- Oxidative imbalance and inflammation are implicated in the pathophysiology of various neuropsychiatric disorders.
Purpose of the Study:
- To assess oxidative imbalance and inflammation in Conversion Disorder patients.
- To evaluate thiol/disulfide homeostasis and C-reactive protein (CRP) levels as potential biomarkers for CD.
Main Methods:
- Ninety-six CD patients and 96 healthy controls were enrolled.
- Psychiatric symptom severity was measured using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI).
- Thiol/disulfide homeostasis and CRP levels were quantified using spectrophotometry and immunoturbidimetry, respectively.
Main Results:
- CD patients showed significantly lower native thiol and total thiol levels (p < 0.001).
- Disulfide levels and disulfide/thiol ratios were significantly higher in CD patients (p < 0.001).
- Elevated CRP levels were observed in the CD group compared to controls (p < 0.001).
Conclusions:
- Findings suggest oxidative imbalance and elevated CRP in CD patients, implicating redox and inflammatory pathways.
- Thiol/disulfide homeostasis and CRP may serve as peripheral biomarkers for Conversion Disorder.
- This is the first study to concurrently assess thiol/disulfide homeostasis and CRP in CD.
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