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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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Related Experiment Video

Updated: May 4, 2026

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
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Hydrogel Microspheres as Versatile Platforms for Biomedical Research: Design, Properties, and Applications.

Meng Yang1,2, Yuanyuan Shi1,2, Feng Wang3

  • 1Department of Sports Medicine Beijing Key Laboratory of Sports Injuries Peking University Third Hospital Beijing China.

Medcomm
|October 13, 2025
PubMed
Summary

Hydrogel microspheres (HMs) offer tunable properties for drug delivery and tissue engineering. This review details their construction, fabrication, and diverse biomedical applications, bridging research to clinical translation.

Keywords:
biomaterialshydrogel microspherestissue engineering

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Area of Science:

  • Biomaterials Science
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Hydrogel microspheres (HMs) are versatile biomaterials with inherent biocompatibility and controlled release capabilities.
  • They are extensively utilized in drug delivery, cell encapsulation, and tissue engineering applications.
  • Current reviews often lack a holistic view, focusing on isolated aspects of HM technology.

Purpose of the Study:

  • To systematically review the construction strategies, fabrication technologies, and multifunctional applications of hydrogel microspheres.
  • To bridge the gap between fundamental research in HM design and their clinical translation.
  • To explore the cross-system therapeutic potential and address challenges in the clinical adoption of HMs.

Main Methods:

  • Summarizing HM construction strategies, including material selection and property modulation.
  • Reviewing fabrication technologies such as batch emulsion, microfluidic chips, and AI-assisted methods.
  • Cataloging multifunctional applications including drug/cell delivery, nanoparticle integration, and lubrication modification.

Main Results:

  • HMs exhibit tunable material compositions (natural, synthetic, composite polymers) and fabrication methods (microfluidics, electrohydrodynamic spraying).
  • Diverse applications span musculoskeletal repair to dermatological therapy, showcasing cross-system therapeutic potential.
  • Key challenges in clinical translation and opportunities for synergistic therapy are identified.

Conclusions:

  • This review provides a comprehensive overview of HMs from basic research to clinical application.
  • It highlights the potential of HMs for advanced therapeutic strategies and synergistic treatments.
  • Addressing identified bottlenecks is crucial for successful clinical translation of HM technology.