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Updated: Jan 15, 2026
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Tuberculosis reactivation in hematopoietic stem cell transplant recipients: a preemptive strategy in an endemic
Irma Karen Pellón-Téllez1, Omar Eduardo Fernandez-Vargas1, Patricia Cornejo-Juárez2
1Department of Hematology, Instituto Nacional de Cancerología, Mexico, Mexico.
Background:
Tuberculosis (TB) remains a global public health issue, particularly in developing countries. Hematopoietic stem cell transplant (HSCT) recipients are at increased risk for TB due to immunosuppression.
Methods:
This retrospective study (2005-2022) assessed a preemptive latent tuberculosis infection (LTBI) screening and treatment strategy in 338 HSCT recipients and their donors. Screening included tuberculin skin test (TST) or QuantiFERON-TB Gold (QFT), and pulmonary imaging, with positive cases receiving isoniazid (INH) therapy before HSCT. Statistical analyses compared TB reactivation rates, overall survival (OS), and relapse-free survival (RFS) across HSCT groups.
Results:
Of 338 patients, screening involved TST in 325 and QFT in 13 cases, resulting in 94 (27.8%) patients with LTBI. INH therapy was completed by 83 patients, with 5 discontinuing due to hepatotoxicity. The cumulative incidence of active TB was 0.6%, and one patient who received INH prophylaxis developed LTBI reactivation. LTBI status did not affect OS or RFS.
Conclusions:
Our study demonstrates that the use of LTBI protocols incorporating TST/QFT and chest CT-scans, followed by INH in positive cases, was safe and is an accessible option among HSCT recipients in high-burden regions.
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