Can the Systemic Immune-Inflammation Index Be a Prognostic Factor for Tympanoplasty Success?

Objective To examine the role of the preoperative systemic immune-inflammation index (SII) in the success of type 1 tympanoplasty. Methods Between 2016 and 2022, 85 out of 442 patients who underwent type 1 tympanoplasty for chronic otitis media (COM) at our clinic met the inclusion criteria. Demographic data, preoperative complete blood count (CBC) results (including the neutrophil-to-lymphocyte ratio (NLR) and SII), audiological test results, computed tomography findings, and six-month follow-up results were evaluated. Results Anatomic outcomes were categorized into two groups based on graft success: Group 1 (64 patients with successful grafting) and Group 2 (21 patients with graft failure), yielding a success rate of 75.3%. Laboratory findings showed no significant differences in hemoglobin, platelet, or lymphocyte values (p>0.05), but neutrophil count (p < 0.05), NLR, and SII values (p < 0.05) were significantly higher in Group 2. The median SII was 509.1 (422.5-596.7) in Group 1 and 609.9 (521.8-790.5) in Group 2. Conclusions In our study, we found a negative correlation between SII, NLR, and type 1 tympanoplasty success. These parameters might be considered new prognostic inflammatory markers for tympanoplasty outcomes.