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A Case of Progestogen Hypersensitivity: Systemic Allergic Response
Hannah R Smith1, Kyler Stephan1, Larry M Fields2
1Obstetrics and Gynecology, Lincoln Memorial University DeBusk College of Osteopathic Medicine, Knoxville, USA.
Abstract:
Progestogen hypersensitivity (PH) is an allergic condition in which women of reproductive age become sensitized to endogenous progesterone and/or exogenous progestins. PH may present as cutaneous manifestations, such as hives, and/or systemic allergic reactions. Allergic flares typically correlate with relative peaks in progesterone during the luteal phase of the menstrual cycle.PH may go unrecognized due to its heterogeneous presentation. In this case report, we discuss a 26-year-old female patient with suspected progestogen hypersensitivity resulting in a monthly systemic allergic response. We also discuss diagnostic factors for PH, pathogenesis, and treatment/management of symptoms.
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