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Multifunctional nanoplatform as nano-inducer of ferroptosis for targeted recognition and imaging-guided therapy of metastatic prostate cancer

  • 0Department of Urology, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Materials Today. Bio +

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October 13, 2025

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October 13, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

A novel nanoplatform, Fe/Au nanodots-bombesin (FGN-BBN), effectively induces ferroptosis in metastatic prostate cancer (PCa) cells. This platform combines imaging and therapy for enhanced treatment outcomes.

Area Of Science

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background

  • Metastatic prostate cancer (PCa) presents significant challenges in precise detection and effective treatment.
  • Ferroptosis induction offers a promising therapeutic strategy for metastatic PCa.
  • Developing efficient methods to induce ferroptosis in PCa cells is crucial for improving therapeutic efficacy.

Purpose Of The Study

  • To develop a multifunctional nanoplatform, Fe/Au nanodots-bombesin (FGN-BBN), for targeted imaging and therapy of metastatic PCa.
  • To utilize FGN-BBN as a ferroptosis nano-inducer through an "open-source throttling" strategy.
  • To enhance ferroptosis induction and enable multimodal bioimaging for theranostic applications.

Main Methods

  • Fabrication of a multifunctional nanoplatform (FGN-BBN) integrating nanozyme and photothermal properties.
  • Utilizing photothermal-enhanced chemodynamic therapy (CDT) to generate reactive oxygen species (ROS) via POD-like activity.
  • Employing GPx-like activity to deplete glutathione (GSH), thereby enhancing ROS-induced ferroptosis.
  • Leveraging bombesin for targeted delivery to metastatic PCa cells.
  • Implementing multimodal bioimaging (fluorescence, CT, MRI) for diagnosis and therapy guidance.

Main Results

  • FGN-BBN demonstrated potent POD-like activity, generating abundant ROS via photothermal-enhanced CDT.
  • FGN-BBN exhibited GPx-like activity, depleting tumor microenvironment GSH and preventing ROS neutralization.
  • Bombesin facilitated targeted delivery, synergistically enhancing ferroptosis in PCa cells.
  • The nanoplatform enabled targeted recognition and multimodal bioimaging for visualization and therapy guidance.

Conclusions

  • The developed FGN-BBN nanoplatform effectively induces high-efficiency ferroptosis in metastatic PCa.
  • This multifunctional platform integrates multienzyme activity, targeted recognition, multimodal imaging, photothermal therapy, and CDT.
  • FGN-BBN offers a promising theranostic strategy for the precise detection and effective treatment of metastatic PCa.

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