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Multiscale interface engineering in biohybrid composites for biomedical applications.

Yi Wang1, Tingyu Wang1, Ran Tang1

  • 1Sichuan Provincial Engineering Research Center of City Solid Waste Energy and Building Materials Conversion & Utilization Technology, Chengdu University, Chengdu, 610106, China.

Materials Today. Bio
|October 13, 2025
PubMed
Summary

Engineered interfaces in multiscale composites are key for advanced biomedical materials. Strategies span nano-to-macro scales, enhancing mechanical properties, biological signaling, and adaptive functions for diverse applications.

Keywords:
Hierarchical designInterface engineeringLiving biomaterialsMultiscale compositesStimuli-responsive systems

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Area of Science:

  • Biomaterials Science
  • Materials Engineering
  • Nanotechnology

Background:

  • Multiscale composites with engineered interfaces are crucial for next-generation biomedical materials.
  • Interface design significantly impacts mechanical performance, biological signaling, and adaptive functionality.

Purpose of the Study:

  • To provide a comprehensive overview of interface design strategies across nano-to-macro scales in biomedical materials.
  • To categorize key approaches and link them to advanced fabrication techniques and biomedical applications.

Main Methods:

  • Review of hierarchical structuring, stimuli-responsive interfaces, and bioinspired/living systems.
  • Analysis of advanced fabrication techniques (additive manufacturing, nanofunctionalization, layer-by-layer assembly).
  • Exploration of multiscale characterization tools for interfacial analysis.

Main Results:

  • Interface engineering strategies modulate mechanical properties, cellular responses, and integration.
  • Specific applications include scaffolds, implants, drug delivery, and neural electronics.
  • Understanding biological interactions (protein adsorption, mechanotransduction, immune modulation) is vital.

Conclusions:

  • Multiscale interface engineering offers a roadmap for developing multifunctional biomaterials.
  • Challenges include scalability, biocompatibility, and regulatory approval.
  • AI-driven design and organ-on-chip models present future solutions.