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Updated: Jan 15, 2026
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Evaluation of NEUROG1 methylation status in stool specimens in the advanced adenomas and colorectal cancer
Lijin Zhang1,2,3, Aiping Lin1,2,3, Jie Lin4
1Department of Gastroenterology, the Shengli Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.
Background:
To assess the status of NEUROG1 methylation in the advanced adenoma and colorectal cancer.
Methods:
The NEUROG1 methylation in tissue and stool samples from patients with colorectal cancer (CRC), advanced adenoma (AA), and non-advanced adenoma (NAA) were evaluated using methylation-specific quantitative polymerase chain reaction (PCR).
Results:
In tissue samples, the NEUROG1 methylation detection rates were 36% for CRC, 24% for NAA, and 88% for AA. In stool samples, the NEUROG1 methylation detection had a sensitivity of 63.46% for CRC with a positive predictive value (PPV) of 85.94%. The overall diagnostic specificity of the test for the NAA and the healthy control was 76.32%, with a negative predictive value (NPV) of 40.28%.
Conclusion:
NEUROG1 methylation detection can potentially be used in the CRC and AA screening.
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