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Related Experiment Video

Updated: Jan 15, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
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Weight-based flow rate triphasic contrast injection protocol for pediatric cardiac computed tomography.

Quan Li1, Jian Li1, Xuehua Peng1

  • 1Department of Radiology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Quantitative Imaging in Medicine and Surgery
|October 13, 2025
PubMed
Summary

A new weight-based contrast injection protocol for pediatric cardiac CT significantly improved image quality and reduced artifacts in children. This method offers stable results for individuals under 18, potentially becoming a standard protocol for pediatric cardiac examinations.

Keywords:
Computed tomography (CT)congenital heart disease (CHD)contrast mediumpediatric

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Area of Science:

  • Radiology
  • Pediatric Cardiology
  • Medical Imaging

Background:

  • Cardiovascular computed tomography (CT) is crucial for pediatric examinations.
  • Current contrast medium flow rates for pediatric CT rely on radiologist experience.
  • Congenital heart disease (CHD) in children necessitates accurate imaging.

Purpose of the Study:

  • To assess a weight-based flow rate triphasic contrast injection protocol for pediatric cardiac CT.
  • To evaluate the protocol's effectiveness in children under 18 with suspected CHD.
  • To optimize contrast delivery for improved diagnostic accuracy.

Main Methods:

  • Prospective enrollment of 90 children using the new protocol; retrospective inclusion of 96 controls.
  • Weight-based flow rates: 0.12 mL/s/kg (<5 kg), 0.1 mL/s/kg (5-40 kg), 0.08 mL/s/kg (>40 kg).
  • Subjective (Likert scale) and objective (CT attenuation, SNR, CNR) image quality assessments.

Main Results:

  • The weight-based protocol significantly improved CT value stability and reduced artifacts in the right atrium and superior vena cava compared to traditional protocols.
  • Objective evaluations of the aorta showed no significant differences between weight groups (P>0.05).
  • Subjective analysis indicated high image quality for most structures, with artifacts not impacting clinical diagnosis.

Conclusions:

  • The weight-based contrast injection protocol achieves stable image quality in pediatric patients (<18 years).
  • This protocol demonstrates potential for routine use in pediatric cardiac CT examinations.
  • Optimized contrast delivery enhances diagnostic confidence in pediatric cardiovascular imaging.