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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Development of the Heart01:27

Development of the Heart

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The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
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Related Experiment Video

Updated: Jan 15, 2026

Isolation, Culture and Transduction of Adult Mouse Cardiomyocytes
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Decoding developmental signaling for heart regeneration.

Thomas W C Knight1, Ngefor Asangwe1, Sadia Mohsin1

  • 1Aging and Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.

Stem Cells (Dayton, Ohio)
|October 13, 2025
PubMed
Summary
This summary is machine-generated.

Adult heart regeneration is limited because cardiomyocytes are not replaced after injury. Reactivating developmental signaling pathways, particularly microRNAs, in cardiac progenitor cells (CPCs) shows promise for cardiac repair.

Keywords:
Cardiac regenerationcardiomyocyte proliferationmiRNAsstem cells

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Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration
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Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration
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Apical Resection Mouse Model to Study Early Mammalian Heart Regeneration

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Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Developmental Biology

Background:

  • The adult heart has a fixed number of cardiomyocytes (CMs) and lacks regenerative capacity after injury, often leading to heart failure.
  • Embryonic and early postnatal hearts possess inherent regenerative potential, capable of complete injury resolution.
  • This regenerative ability is linked to unique developmental cellular and molecular mechanisms that are suppressed in the adult heart.

Purpose of the Study:

  • To review strategies for reactivating developmental signaling pathways to promote cardiac repair in the adult heart.
  • To focus on the role of cardiac progenitor cells (CPCs) and cardiomyocytes (CMs) in this process.
  • To emphasize the significance of embryonic/developmental microRNAs in governing signaling pathways for cardiac regeneration.

Main Methods:

  • Summarizing existing research on developmental signaling reactivation for cardiac repair.
  • Analyzing the use of CPCs engineered with developmental factors.
  • Investigating cell-specific delivery of factors to CMs to reactivate regenerative signaling.

Main Results:

  • Reactivation of developmental signaling can augment cardiac structure and function in the adult heart.
  • Engineering CPCs or delivering factors to CMs can harness regenerative potential.
  • Embryonic/developmental microRNAs play a crucial role in signaling pathways that facilitate cardiac repair.

Conclusions:

  • Reactivating developmental signaling, especially via microRNAs, offers a promising therapeutic avenue for adult heart repair.
  • Utilizing CPCs and CMs holds potential for enhancing regenerative signaling.
  • Further research is needed to overcome limitations and optimize these approaches for clinical application.