Related Experiment Video
Updated: Jan 15, 2026
10:29
Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
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Cardiovascular Risk Assessment Using the Atherosclerotic Cardiovascular Disease Risk Score Model after Continuing or
Priscilla Y Hsue1, Georg M N Behrens2, Zhi Jin Xu3
1UCLA, Los Angeles, CA.
Journal of Acquired Immune Deficiency Syndromes (1999)
|October 13, 2025
Summary
Doravirine (DOR)-based regimens did not alter atherosclerotic cardiovascular disease (ASCVD) risk scores in people living with HIV (PLWH) over four years. This suggests DOR is a safe treatment option for PLWH, who face higher ASCVD risks.
Area of Science:
- Cardiology
- Infectious Diseases
- Pharmacology
Background:
- People living with HIV (PLWH) on antiretroviral therapy have an elevated risk of atherosclerotic cardiovascular disease (ASCVD).
- Doravirine (DOR), a nonnucleoside reverse transcriptase inhibitor, is known for its favorable lipid profile and minimal weight impact, suggesting it may not increase ASCVD risk.
Purpose of the Study:
- To evaluate the impact of doravirine (DOR)-based antiretroviral therapy on ASCVD risk in people living with HIV (PLWH).
Main Methods:
- A post hoc analysis of two Phase 3 trials (DRIVE-FORWARD and DRIVE AHEAD) involving 369 participants.
- Participants received DOR-based regimens or comparator regimens for 96 weeks, with optional open-label extensions up to 192 weeks.
- 10-year ASCVD risk scores were calculated at baseline and multiple follow-up visits.
Main Results:
- No significant changes in ASCVD risk scores were observed with DOR-based regimens over approximately four years.
- A slight trend toward increased ASCVD risk in men at week 192 was attributed to natural aging rather than the DOR treatment.
Conclusions:
- DOR-based regimens are not associated with increased ASCVD risk scores in PLWH.
- DOR may be a suitable therapeutic option for PLWH, considering the heightened burden of HIV-associated ASCVD.
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