Related Experiment Video For Kidney disease
Updated: Jan 15, 2026
Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
Published on: November 23, 2012
PET imaging of mitochondrial complex-I in the adenine-induced tubulointerstitial nephropathy mouse model using
Kenneth Dahl1,2, Peter Johnström3,4, Miklós Toth4
1PET Science Centre, Precision Medicine and Biosamples, Oncology R&D, AstraZeneca, Karolinska Institutet, Stockholm, Sweden. kenneth.dahl@astrazeneca.com.
Background:
Chronic kidney disease (CKD) poses a significant global health burden with limited effective treatments for its prevention, progression, and associated complications. Mitochondrial dysfunction is recognized as a pivotal factor in the development of kidney diseases, with mitochondrial complex-I (MC-I) playing a crucial role in assessing overall mitochondrial function. Recent advancements in selective MC-I positron emission tomography (PET) radioligands now allow for non-invasive visualization and quantification of renal mitochondrial status in vivo. The aim of the present study was to evaluate the utility of [18F]BCPP-BF in the adenine induced tubulointerstitial nephropathy model.
Results:
Binding of the MC-I targeted PET radioligand, [18F]BCPP-BF, showed a gradual decline in the kidneys of mice on an adenine-rich diet. [18F]BCPP-BF binding decreased by 59-61% compared to baseline after two weeks of adenine treatment. These results of reduced uptake were further confirmed by in vitro autoradiography. In kidneys from adenine-fed mice, [18F]BCPP-BF specific binding was reduced by 65.6% compared to control kidney sections.
Conclusions:
Altogether, the findings suggest that [18F]BCPP-BF holds potential as an imaging biomarker for renal failure. However, further preclinical studies and validation in human subjects are necessary before it can be established as a reliable indicator for the progression of CKD.
