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From infection to intervention: post-acute sequelae of SARS-CoV-2 infection and cardiovascular risk

  • 0Faculty of Pharmacy, Integral University, Lucknow, UP, India. rufaidaw@iul.ac.in.
Inflammopharmacology +

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October 13, 2025

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October 13, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Long COVID, a post-SARS-CoV-2 condition, causes persistent cardiovascular symptoms like arrhythmias and heart failure. Further research is needed to understand its cellular basis and identify predictive biomarkers.

Area Of Science

  • Cardiology
  • Infectious Diseases
  • Pathophysiology

Background

  • COVID-19 is a global epidemic with long-term, multi-organ effects, including cardiovascular complications.
  • Long COVID symptoms can persist for weeks or months post-SARS-CoV-2 infection, impacting various organ systems.
  • Common cardiovascular manifestations include electrocardiogram abnormalities, postural orthostatic tachycardia, and arrhythmias.

Purpose Of The Study

  • To investigate the cardiovascular and vascular implications of long COVID.
  • To explore potential mechanisms behind long COVID cardiovascular symptoms, including perimyocarditis and microthrombosis.
  • To assess the predictive value of current biomarkers for long COVID outcomes.

Main Methods

  • Utilized cardiac and vasculature imaging to identify cardiovascular changes.
  • Analyzed persistent perimyocarditis, ventricular dysfunction, arterial inflammation, and microthrombosis in affected patients.
  • Evaluated circulating coagulation and inflammatory markers at three months post-SARS-CoV-2 infection.

Main Results

  • Cardiac and vascular imaging revealed persistent post-infectious perimyocarditis, leading to potential ventricular failure, arterial inflammation, and microthrombosis.
  • Current biomarkers (coagulation, inflammatory markers) showed limited predictive value for long COVID existence or outcomes at three months.
  • The study highlights the need for deeper understanding of cellular and molecular processes driving long COVID.

Conclusions

  • Long COVID presents significant cardiovascular challenges, including potential heart failure and vascular damage.
  • Current biomarkers are insufficient for predicting long COVID cardiovascular complications.
  • Further research into the underlying pathophysiology and novel biomarkers is crucial for effective prevention and treatment strategies.

Keywords:

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