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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
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Aging-Related Mechanisms Underlying Carcinogenesis: Therapeutic Opportunities
Ana Guijarro1, Giulia Allavena2, Livia Pisciotta1,3
1Department of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.
Aging and Disease
|October 13, 2025
Summary
Aging accelerates cancer risk and progression. Therapies targeting aging mechanisms may also prevent cancer and reduce treatment side effects, but require careful consideration in older adults.
Area of Science:
- Gerontology
- Oncology
- Molecular Biology
Background:
- Aging is a primary risk factor for cancer, with 64% of diagnoses in individuals over 60.
- Cancer remains a leading cause of death globally, despite therapeutic advancements.
Purpose of the Study:
- To explore the intricate relationship between aging processes and cancer development.
- To identify potential anti-aging therapies that could also impact cancer prevention and treatment.
Main Methods:
- Review of established aging mechanisms including somatic mutations, genomic instability, and cellular senescence.
- Analysis of how these aging hallmarks contribute to cancer initiation and progression.
- Evaluation of potential therapeutic interventions targeting aging processes.
Main Results:
- Aging hallmarks such as DNA damage, inflammation, and stem cell exhaustion are critical in cancer.
- Interventions like exercise, diet, and senotherapeutics show promise in mitigating both aging and cancer.
- Aging and cancer share common molecular pathways, highlighting interconnectedness.
Conclusions:
- Aging and cancer are closely linked, sharing underlying biological mechanisms.
- Targeting aging processes offers a novel strategy for cancer prevention and treatment.
- Personalized approaches are crucial for older cancer patients, balancing efficacy with quality of life.
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