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Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...

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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

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The Circadian Rave System: An Affordable, Open-Source, and Easy-to-Build System for Any Light-Based Experiments.

Terrence M Trinca¹, Oscar A Peña², Amy Preston³

¹School of Biochemistry, University of Bristol; terrence.trinca@bristol.ac.uk.

Journal of Visualized Experiments : Jove

|October 13, 2025

Summary

This summary is machine-generated.

Researchers developed the Circadian Rave System for precise light control in circadian rhythm studies. This open-source, affordable system enhances experimental standardization and scalability for biological research.

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Area of Science:

Chronobiology
Neuroscience
Genetics

Background:

Circadian clocks regulate physiology and behavior, entraining to the 24-hour day.
Studying circadian rhythms requires experimental manipulation of light or temperature.
Current lighting systems lack precision, standardization, and affordability.

Purpose of the Study:

To develop a standardized, scalable, and affordable lighting system for circadian research.
To provide open-source software and hardware build guides for in-house construction.
To enable precise control of light environments for circadian experiments.

Main Methods:

Developed the Circadian Rave System, a software and hardware package.
Designed for precise control of multiple independent light boxes.
Demonstrated functionality using Drosophila melanogaster longevity and activity assays.

Main Results:

The Circadian Rave System allows precise control over light paradigms.
Demonstrated circadian synchronization and disruption through light manipulation in Drosophila.
The system is scalable, affordable, and can be built with minimal expertise.

Conclusions:

The Circadian Rave System offers a standardized solution for lighting control in circadian research.
Open-source availability promotes widespread adoption and reproducibility.
This system empowers researchers to conduct more precise and standardized circadian experiments.