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Eric Jaziel Medrano-Sánchez1, Ammy Joana Gallegos-García2, Ricardo López-Rodríguez1

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Summary

Montanoa tomentosa extracts and isolated compounds show significant anti-inflammatory activity. Kaurenoic acid derivatives, like compound 6, are particularly effective in reducing inflammation, highlighting their therapeutic potential.

Keywords:
AsteraceaeMontanoa tomentosaanti‐inflammatoryterpenoids

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Area of Science:

  • Ethnobotany and Phytochemistry
  • Pharmacology and Toxicology

Background:

  • Montanoa tomentosa, used in Mexican traditional medicine, possesses anti-inflammatory properties.
  • Leaves of M. tomentosa are a rich source of bioactive metabolites.

Purpose of the Study:

  • To evaluate the anti-inflammatory activity of M. tomentosa leaf extracts (n-hexane, ethyl acetate, methanol) and isolated compounds.
  • To identify specific anti-inflammatory compounds from M. tomentosa.

Main Methods:

  • Anti-inflammatory effects were assessed using the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model in mice.
  • Compounds were isolated and structurally characterized using nuclear magnetic resonance (NMR) spectroscopy.

Main Results:

  • The n-hexane extract (MtHex) significantly reduced ear edema (61.16 ± 3.8%), comparable to indomethacin.
  • Six compounds were isolated: β-sitosterol, stigmasterol, kaurenoic acid, grandiflorenic acid, taraxasterol, and 15-cinnamoylkaurenic acid.
  • 15-cinnamoylkaurenic acid (compound 6) exhibited the most potent anti-inflammatory effect (79.05 ± 3.07%).

Conclusions:

  • M. tomentosa is a valuable source of terpene-type metabolites with significant anti-inflammatory potential.
  • Kaurenoic acid derivatives and sterols from M. tomentosa warrant further investigation for their therapeutic applications.