[Predictive value of seram urea nitrogen to albumin ratio for all-cause mortality in patients with acute ischemic stroke]
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View abstract on PubMed
Summary
This summary is machine-generated.The blood urea nitrogen to albumin ratio (BAR) may predict one-year mortality in acute ischemic stroke (AIS) patients. Higher BAR levels were associated with increased mortality risk, suggesting BAR
Area Of Science
- Neurology
- Clinical Biochemistry
- Public Health
Background
- Acute ischemic stroke (AIS) is a leading cause of mortality and disability worldwide.
- Effective risk stratification tools are crucial for managing AIS patients.
- The blood urea nitrogen to albumin ratio (BAR) is a potential biomarker for various health conditions.
Purpose Of The Study
- To investigate the association between serum BAR and one-year all-cause mortality in patients with AIS.
- To evaluate BAR's predictive value for mortality in AIS patients.
- To assess if BAR can improve existing risk prediction models.
Main Methods
- Analysis of data from the third Chinese National Stroke Registry (n=4,635 AIS patients).
- Patients were stratified into quartiles based on serum BAR.
- One-year follow-up for mortality, analyzed using multivariable Cox regression and restricted cubic spline (RCS) analysis.
- Receiver operating characteristic (ROC) analysis was used to assess predictive performance.
Main Results
- Mortality rates increased progressively across BAR quartiles (Q1-Q4).
- The highest BAR quartile (Q4) showed a 2.35-fold higher mortality risk compared to the lowest (Q1).
- BAR demonstrated a moderate predictive ability for one-year mortality (AUC=0.667), which improved significantly when combined with traditional risk factors (AUC=0.764).
Conclusions
- Serum BAR is independently associated with one-year all-cause mortality in AIS patients.
- BAR may serve as a valuable biomarker for risk stratification in AIS.
- Combining BAR with established risk factors enhances the prediction of mortality in AIS patients.
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